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We Built Our Own Salesforce in Months. Here's Why We're Cancelling the $600K Contract | Curative CEO

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We Built Our Own Salesforce in Months. Here's Why We're Cancelling the $600K Contract | Curative CEO
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Fred Turner is the Founder and CEO @ Curative, one of the wildest stories in tech. Fred scaled a COVID testing business from $0 to $5BN in revenue and took the team from 7 to 7,000 employees in just 9 months. They did over 206,000 COVID tests in a single day and signed contracts in the 100s of $Ms with several of the largest states. Today, Curative is a unicorn health insurance business taking on the incumbents for one of the largest markets in healthcare. ----------------------------------------------- Timestamps: 00:00 Intro 01:07 – Meet Fred Turner: thrill of winning vs. fear of losing 02:01 – Why he couldn't have built this business in the UK 03:40 – From cattle genetics to sepsis to Covid (the origin story) 07:54 – Pivoting into human diagnostics and at-home STD testing 14:43 – Founding Curative on a sepsis thesis, before Covid changed everything 18:44 – Covid hits: pivoting overnight into mass testing 27:03 – Building an "orthogonal supply chain" to scale testing 10x 30:44 – $5B in revenue, brutal margins, and losing money on vaccines 35:32 – The pivot to health insurance after Covid winds down 41:39 – How AI agents replaced entire back-office departments 45:48 – Is SaaS dead? Cutting Salesforce and 80% of SaaS spend 1:13:06 – Subcritical: building a fundamentally safer nuclear reactor ---------------------------------------------------------------------------------------------- Subscribe on Spotify: https://open.spotify.com/show/3j2KMcZTtgTNBKwtZBMHvl?si=85bc9196860e4466 Subscribe on Apple Podcasts: https://podcasts.apple.com/us/podcast/the-twenty-minute-vc-20vc-venture-capital-startup/id958230465 Follow Harry Stebbings on X: https://twitter.com/HarryStebbings Follow Fred Turner on X: https://twitter.com/FredTurnerBio Follow 20VC on Instagram: https://www.instagram.com/20vchq Follow 20VC on TikTok: https://www.tiktok.com/@20vc_tok Visit our Website: https://www.20vc.com Subscribe to our Newsletter: https://www.thetwentyminutevc.com/contact ---

Summary

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At-a-Glance

  • Verdict: Watch fully
  • Core thesis: Curative's founder argues that extreme operational scaling comes from rebuilding systems around the actual constraint, while current-generation AI agents can now automate nearly all standardized back-office work and let regulated incumbents compete through radically lower operating costs and faster execution.
  • Why it matters: This is a concrete field report on deploying agents with real authority in a heavily regulated, high-stakes industry: replacing credentialing, data ingestion, contracting, CRM, claims workflows, and legacy SaaS rather than merely adding copilots.
  • Best use: Use it as an operating case study for agent-native control planes: identify repetitive workflows, define approval guardrails and exception queues, give agents tool access, and redeploy humans toward technical oversight and high-value relationships.

Executive Summary

Fred Turner recounts Curative's path from a failed diagnostics startup to a COVID-testing operator that went from roughly 7 to 7,000 employees in nine months, processed a peak of 206,000 tests in one day, and generated about $5 billion of revenue over three years. The central operating lesson was not conventional efficiency but designing for the binding constraint: during COVID, established labs could optimize steady-state operations but could not expand capacity 10x. Curative built an "orthogonal supply chain" around alternative inputs and suppliers rather than competing for the scarce materials everyone else was buying.

After COVID, Curative used approximately $500 million of accumulated capital to become a health insurer, based on the view that the payer—not the hospital, testing lab, or provider—is the practical control point in US healthcare because payment policy determines provider and patient behavior. Turner views market consolidation as a major source of healthcare inefficiency: hospital systems can use must-have facilities to secure roughly double reimbursement for affiliated primary-care doctors versus independent doctors performing the same service.

The highest-signal portion is Curative's AI implementation. Turner says the company has moved from expecting selective automation to believing current models can perform every one of its back-office workflows, provided agents are properly configured, constrained, and supervised. Its Claude-based credentialing agent cut average turnaround from two to three months to 12 hours and cost from about $50 to $0.20. For unstructured broker and provider files, agents generate and execute disposable Python scripts to transform each one-off input into a standardized format rather than requiring senders to conform to a rigid intake template.

Curative is using agents not only for internal processing but for external action. Its contracting agent, Gwen, researches providers, sources contact information, persistently sends tailored outreach, negotiates rates and contract language within preset guardrails, edits documents via generated Python, and signs via DocuSign using Turner's signature. The result was a move from about 100 provider contracts per week to 100 per day; Gwen completed 3,500 contracts in roughly eight weeks versus 2,300 completed by the entire team in the preceding year. The company's organizational conclusion is that routine administration will shrink sharply, while technical architecture, exception supervision, and trust-based relationships remain human-centered.

Key Takeaways

  • Claim: When demand changes discontinuously, optimize for scalable capacity around the true bottleneck rather than incremental efficiency within the incumbent process. | Evidence: Curative's COVID-testing operation avoided the constrained inputs used by other labs: it sourced swabs from electronic-testing suppliers and sterilized them, and used scalable glass-and-plastic filter plates instead of magnetic beads sourced largely from two Chinese factories. It reached 206,000 tests in one day by December 2020. | Implication: For rapid-scale systems, map capacity dependencies first and construct alternate supply, tooling, or execution paths that increase total system throughput rather than fighting competitors for the same scarce resource. | Caveat: Turner explicitly says this overbuilt, surge-oriented model does not work under normal stable demand; maintaining capacity during testing lulls caused Curative to lose money on each test.
  • Claim: AI agents can eliminate whole manual back-office workflows in regulated operations when they are given browser, document, and approval capabilities—not merely chat interfaces. | Evidence: Curative replaced its credentialing process—checking clinician licenses, educational records, and malpractice information—with an in-house Claude agent. Average turnaround fell from two to three months to about 12 hours, and cost fell from approximately $50 to $0.20 per credentialing event. | Implication: High-volume compliance workflows are strong early agent targets when source systems are accessible, the required evidence can be enumerated, and exceptions can be explicitly routed. | Caveat: The workflow is suitable because its verification steps and approval criteria can be operationalized; the transcript does not provide error rates, audit outcomes, or details of human escalation for disputed cases.
  • Claim: One-off unstructured data does not necessarily require a large data-cleaning or universal-integration project; agents can generate disposable transformation code per input. | Evidence: For underwriting submissions arriving as inconsistent spreadsheets and PDFs, Curative asks an agent to write Python that converts each specific file set into its known internal format, test and iterate the script, then discard it. Turner says the process completes in about 15 minutes and allows senders to provide whatever format they already have. | Implication: Build agent workflows around code generation and verification rather than assuming the model must natively manipulate every enterprise file type. This reduces integration friction and removes unnecessary format mandates on counterparties. | Caveat: Turner notes that models are not inherently strong at directly parsing files or editing Word documents; the effective pattern is having the model generate code to perform those tasks.
  • Claim: Agents create outsized value when they execute an entire revenue or operations loop—including research, persistent outreach, negotiation, document changes, and authorized signing—within policy guardrails. | Evidence: Curative's provider-contracting agent, Gwen, researches a practice, finds contact data via ZoomInfo, uses public transparency files to estimate payer rates, sends customized follow-ups, negotiates and redlines agreements, and signs through DocuSign. It increased output from roughly 100 contracts per week to 100 per day; Gwen alone completed 3,500 contracts in about eight weeks. | Implication: The relevant unit of automation is not a task but a bounded commercial workflow. Equip agents with authority for routine decisions and reserve humans for material exceptions, strategic accounts, and relationship-intensive negotiations. | Caveat: Gwen is constrained by guardrails, including margin thresholds that trigger approval requests; large hospital systems and larger physician groups still require human calls and relationship management.
  • Claim: Custom agent-native software can displace a substantial portion of enterprise SaaS when it is built around a company's specific workflows, but infrastructure-like systems have higher switching costs. | Evidence: Curative cancelled a $600,000-per-year Salesforce contract after building a more integrated internal CRM in roughly two months, and plans to cut about 80% of SaaS spend in the year discussed. It is also replacing a difficult-to-integrate claims platform with an in-house system, while Slack has been harder to replace because of accumulated integrations and workflows. | Implication: Audit SaaS by workflow specificity, total administrative overhead, data accessibility, renewal dates, and embedded integrations. Prioritize systems where custom workflows and integrated agents yield strategic advantage; treat deeply embedded infrastructure as a later migration. | Caveat: Turner identifies maintenance as a real challenge and does not claim every company currently has the technical capacity to replace SaaS. He expects the key question to be timing and technical capability, not whether the transition eventually occurs.
  • Claim: AI-driven organizations should not simply reduce headcount; they should concentrate human capacity in technical oversight, exception handling, and relationship-based work. | Evidence: Curative expects to move from about 650 people toward roughly 400 in the near term as backend workflows are automated, but it retained its 45-person contracting team for complex provider relationships and uses care navigators as continuing human points of contact for members. Turner says one senior engineer can increasingly oversee multiple downstream agents and act as reviewer and architect rather than primary coder. | Implication: Plan workforce redesign alongside deployment: define agent owners, escalation SLAs, decision-right thresholds, audit mechanisms, and a human relationship model before increasing autonomous workflow volume. | Caveat: Automation creates an exception-management bottleneck: even a 1% escalation rate becomes much larger in absolute terms when agents produce 10x the volume. Turner identifies "agent supervisor" as a likely major new role.
  • Claim: In US healthcare, the payer is the most powerful leverage point for changing system behavior because it controls the flow of dollars. | Evidence: Curative considered lab testing, hospital ownership, primary-care chains, and preventive-care plays before choosing insurance. Turner concluded that hospitals face fragmented payer demands, whereas payers directly determine which services are reimbursed. He cites affiliated primary-care doctors receiving about twice the reimbursement of independent peers because consolidated hospital systems bundle access to essential beds and specialty facilities. | Implication: For healthcare investment or operating strategy, distinguish between solving a clinical problem and owning the incentive mechanism that governs adoption, utilization, and reimbursement. | Caveat: This is Turner's strategic interpretation from operating a health insurer, not a comprehensive policy analysis; he also notes that the medical-loss-ratio rule requires insurers to spend 85% of premiums on care, which can perversely reward higher total spending.

Detailed Brief

Building through failure, timing, and temporary-market discipline

  • Claims: Turner's prior company, Shield, pivoted from cattle genetics to human diagnostics and sepsis testing after investors concluded the US cattle-testing market could only support about $1.5 billion in annual total addressable market even under maximal penetration.; A signed Series B term sheet from a strategic diagnostics company failed when that company's CEO killed the transaction because it competed with core products, leaving Shield with roughly three weeks of cash and forcing wind-down.; Curative began as a sepsis-care-delivery company, not a testing company. COVID disrupted its first hospital pilot and created the opening to deploy a test that its chief scientific officer had built during evenings and weekends.
  • Evidence: Shield sold its laboratory license for $150,000 in late 2019 during wind-down, then Curative later paid $27 million to acquire a different licensed lab operation once COVID made the asset strategically essential.; Curative funded the $27 million buyout through forward revenue from early testing customers, including local police and fire departments; its first major Los Angeles contract originated after investor Laura Deming tweeted that the company had testing capacity.; Turner told early COVID hires their roles were likely three-month jobs and began searching for a post-pandemic business while COVID revenues were still growing.
  • Caveats: The COVID opportunity was unusually shaped by emergency demand, accelerated public procurement, and reimbursement structures; its scaling economics should not be generalized to ordinary markets.; The transcript contains repeated passages, but no additional material evidence contradicts the core account.
  • Implications: Failed companies can create reusable assets, regulatory knowledge, and operational lessons, but founders should not confuse a strategic asset's normal market value with its value under a changed external regime.; Temporary demand should be treated as a financing and capability-building window, not proof of a durable standalone market.

Agent economics, governance, and the likely organizational model

  • Claims: Turner believes model expenditure can rationally exceed direct human labor cost because agents do not merely replace existing work; they enable materially more volume and faster service.; Curative's Anthropic spend reportedly grew approximately 6x per month for six or seven months, from tens of thousands of dollars to millions per month, because teams kept identifying new workflows to automate.; Turner expects agent trust to evolve from assistance toward delegated authority, but regards policy guardrails and approval routing as necessary for consequential actions.
  • Evidence: A provider contract reportedly costs $1,500-$2,000 using people versus about $70 through Gwen; Turner says the use case would still work if Anthropic's prices doubled or even increased 5x.; Gwen sends about 15,000 customized emails per day, and Turner attributes much of its effectiveness to persistent follow-up—providers often respond around the ninth email.; For contract authority, Curative lets Gwen sign only against a law-firm-drafted standard agreement and predefined terms it may accept; nonstandard economics create approval requests.
  • Caveats: The stated model-spend growth and future price tolerance are company-specific assertions rather than independently validated unit economics.; High-volume autonomy raises legal, reputational, security, and model-error risks that require controls beyond the guardrails described in the interview.
  • Implications: Token cost should be measured against avoided cycle time, expanded throughput, quality of responsiveness, and strategic coverage—not only against the salary of the employee whose task was automated.; The scaling constraint shifts from raw execution capacity to governance capacity: exception triage, monitoring, policy design, and authorization become core operating functions.

Notable Concepts & Terms

  • Orthogonal supply chain: Curative's term for using alternate inputs and suppliers rather than competing for the same constrained supplies as incumbents; it enabled pandemic-scale testing capacity.
  • Medical loss ratio: The requirement that 85% of collected insurance premiums be spent on care; Turner argues this caps nominal insurer margins but can perversely incentivize higher aggregate healthcare spending.
  • Gwen: Curative's provider-network contracting agent, which performs research, outreach, negotiation, redlining, and authorized signing for routine provider contracts.
  • Single-use code: The pattern of having an agent generate, test, execute, and discard a custom Python script for a specific unstructured input rather than maintaining a universal importer.
  • Agent supervisor: A proposed emerging role responsible for resolving the growing exception queue created when autonomous agents scale workflow throughput.
  • Payer control point: Turner's view that insurers, by determining reimbursement, are the principal mechanism for influencing behavior across the US healthcare system.
  • Subcritical / energy amplifier: Turner's nuclear-fission venture and its design concept: operating below criticality and using a particle accelerator to supply additional neutrons, so turning off the accelerator stops the reaction.

Operator Notes / Why Ken Should Care

  • Select one document-heavy or verification-heavy workflow and run a 30-day agent pilot with measurable baseline metrics: cost per case, turnaround time, exception rate, audit accuracy, and human-review load.
  • Implement a policy layer before authorizing agents to act externally: permitted terms, spend or margin limits, escalation triggers, signing authority, immutable logs, and periodic sample audits.
  • Add an exception-operations owner to every scaled agent program; model expected escalation volume at 10x throughput rather than evaluating exception rates in isolation.
  • Create a SaaS renewal ledger that identifies systems with high seat cost, dedicated administrators, poor APIs, proprietary workflow lock-in, and low infrastructure criticality; assess each for replacement by an internal agent-native workflow.
  • Use the disposable-code pattern for intake and migration projects: have agents generate isolated transformations with test fixtures, retain output and audit artifacts, and discard unneeded code rather than prematurely building universal parsers.
  • For high-value outbound workflows, test controlled persistent follow-up sequences with explicit contact-frequency caps, opt-out handling, and escalation to humans for strategic accounts.

Source/Metadata

  • Title: From 7 to 7,000 Employees in 9 Months | Curative Co-founder & CEO
  • Transcript words: 19834
  • Duration seconds: 5375
  • Timestamp note: No timestamps or chapter markers were present in the supplied transcript.

Transcript

17083 words en Processed in 777.4s

Lockdowns had just started. Everybody was starting to freak out. There was nowhere to get a test. So our chief scientific officer had, in his spare time, developed a COVID test. I think our peak day was 206,000 people tested in a single day. I'm so excited for a freaking wild story today. Fred Turner, co-founder and CEO of Curative. This is an English founder in the valley who scaled a COVID testing business to $5 billion in revenue. Then he had to scale it all back. It did not last post-COVID for obvious reasons. Today, he turned it into a health insurance provider that's worth $1.3 billion. And in the show, he says some pretty wild stuff. And the company went from about 7,000 to 7,000 employees in those first nine months. We did 2.5 million vaccinations. That was another service we did. We also lost a ton of money on that. That was a terrible business. We're cutting about 80% of our SaaS spend this year. What's the single largest contract you signed? Ready to go? Brad, I'm so excited for this, dude. You have the most wild story. And I heard it from Justin first, and then from Anil. So thank you so much for joining me, man. Yeah, thanks for having me. Now, I always find it very telling. Entrepreneurs are often compelled either by the fear of losing or by the thrill of winning. If I were to ask you which one drives you more, what would you say it is? Thrill of winning. I feel like during, certainly during COVID, with some of what we built at Curative, I got a taste for the speed at which you can move when everything is behind you and all the momentum is behind you. And I've been chasing that ever since. That is the biggest tailwind that one could have ever expected. We're going to get to that. You actually grew up in the UK. And then you moved to Silicon Valley very young. 17? 19. 19. Yeah. Okay. Could you have built the business that you did in the UK? No, definitely not. Why is that? I just think the UK doesn't have some of the infrastructure for startups and investing, of that many people that have done a startup before and then are willing to invest in the next generation, particularly investing in younger people. I tried to raise a venture round in the UK and I couldn't even get meetings. This was when I was 18. I was in first year of college and I was doing this startup on the side, and I couldn't even get meetings with, I think I got one fund to take an associate meeting with me. Naturally it went very far. Yes. And so it seemed like people were more investing purely on credentials. And this was a while ago, right? This was more than 10 years ago, but it seemed like people were investing just on, oh, well, you came out of this university. So if you're an undergrad, how could we possibly look at this? This doesn't make any sense. Whereas you go to Silicon Valley and it was like, well, what's the possibility here? What could you envision in 10 years if everything succeeds? How big a company could this be? It was a very different mindset that they were optimizing for how to get the best outcome rather than, I always felt like in the UK, it was optimizing for mitigating the worst downstream outcome. Yes. How do I not get fired? Right. Yeah. I totally get that. That's very funny. Okay. And so we decided to move to the Valley. Great. How does, because we go from sepsis detection, no? Well, cows to sepsis to... Can you just walk me through how we go from cows to sepsis to COVID, just so I understand this? Yeah. So my first company that started... I've never said that statement before in a 20 VC episode, by the way. There we go. It's a new phrase for you. Yes. So I went from initially cattle testing through sepsis to COVID. So it started off, my first company in the UK, which was called TL Biolabs at the time, sequencing dairy and beef cows to predict various traits about the animal from an early age. So it started off with beef. You can predict that certain cows are going to have more musculature from an early age. And some cows can have too much musculature and then they have trouble giving birth. And so there's an optimum that you're shooting for. And I found this completely by chance. I won the UK national science engineering competition and was on TV a little bit. And this farmer reached out to me because he wanted help testing his cows. And he was sending his samples to the Netherlands and it was taking weeks and it was terrible. And I initially told him, I'm not interested in cows. I was interested in human genetics at the time. No, thank you. And then he kept pressing, and he sent me samples with a check attached to the front. And I was like, oh, okay. This is interesting. And so I did the first batch of samples for him, and then all of his friends started sending me samples. And so it grew from there. And this was all still in the north of England. I was in the first year of college at the time. And we started branching out into dairy and predicting how much milk animals would make. And I tried to raise the first venture round for the company in the UK. Didn't get very far. And so I ended up going to the US for the US AgTech investing conference in San Francisco. It was my first time in the States, never been before. And it was my last-ditch attempt to try and raise some money. And I met a bunch of VCs, didn't raise any money, but I did meet a guy who had just finished doing Y Combinator. And he was like, oh, you need to apply to YC. That's what you need to do. You need to move the company to the US. You need to apply to YC. That's the only thing you can do here. And I was familiar with YC, but had never applied. What year was this? This was the end of 2015. Okay. Yeah. So I went back to the hotel room and it turned out the application deadline was six days away. So I was like, all right, it's meant to be. So I did the application, got the interview, came back for the interview, and then moved to Silicon Valley for the summer 16 batch. Paul, so how was the interview? Who was it with? Tim, Jeff, and somebody else. Yeah, it was, I mean, it was all a bit of a blur. It's very fast. And then you found out you get in. Yes. You moved to the Valley. Moved to the Valley. And then it was the same, pitched the same company. We were doing mostly dairy testing at that point, so testing dairy cows to try and predict their milk yield, which for farmers is actually very valuable because they don't make milk until they're 18 months old. And so from day one, all your animals have to have a calf every year to keep making milk. So your herd doubles every year. Is this still the same Curative company? No, this is a completely different company. Okay. I was about to say, God, this is where investing is so difficult because if you hear a founder pitching milk yield optimization, and I'm sure it is logistically a big town, I'm sure. Well, not big enough. That was the problem. Okay. Yeah. So we did this, went through YC, and we raised a seed round from Andreessen. We raised a seed round from Andreessen? Yeah. Their bio fund did our seed round right out of YC. And I don't think they did the TAM calculation. They back found us. Credit to you. Yeah. They were like, oh, this sounds interesting. And then they did the round. It was a small round. And it was like 1.65 million. So, chum change. It's for the coffee. It was, for Andreessen, a small round. Sure. And so we kept developing the technology. We had customers. And then we went to go raise an A. And then people did do the TAM calculation. And there's about 100 million cows in the US. If you're doing well, you could charge 15 to $20 per test. So even if you assume you could test every cow every year, you'd be at 1.5 billion total market, which is not enough to do a series A off of. And so what we ended up doing is taking some of the core DNA testing technology that we had developed and pivoting and using that for human diagnostics. And so that was my first foray into healthcare. We actually first launched a high-throughput STD testing lab. Yeah. And we launched an at-home STD test. That was tons of fun. It was. It was for Andreessen, it was a small round. Sure. And so we kept developing the technology. We had customers. And then we went to go raise an A. And then people did do the TAM calculation. And there's about 100 million cows in the US. If you're doing well, you could charge 15 to $20 per test. So even if you assume you could test every cow every year, you'd be at 1.5 billion total market, which is not enough to do a series A off of. And so what we ended up doing is taking some of the core DNA testing technology that we had developed and pivoting and using that for human diagnostics. And so that was my first foray into healthcare. We actually first launched a high-throughput STD testing lab. Yeah. And we launched an at-home STD test. That was tons of fun. It was. I used to run a lot when I was young, and my knees were wonderful. And I used to love how I built this because they would ask the questions like this, which is: how do you go from cows and musculature on cows and milk yield optimization to at-home STD testing? It doesn't feel that natural a jump. Yeah. On the back end, it's more natural, right? All of these things have DNA in them. And so if you're looking to do better DNA testing, you're just looking for markets where people care more about that. And anything human, people obviously care a lot more about, are more willing to pay for, and are much larger markets. And so we did a market-first approach of where could there be interesting things? And we narrowed in on antibiotic resistance in STDs as being a particularly interesting area where they're getting harder and harder to treat because you get more and more antibiotic resistance. And if you're doing the DNA testing, you can predict what the best drug is going to be early, treat with that drug, and then you're not using the most aggressive antibiotics. Do we have more STDs than ever? Yeah. Yeah. This conversation is a bit too summarize, so it's better. But I thought we were having less sex than ever. Yeah, but more STDs. Wow. Yeah. That's worrying. Yeah, it is. And it's been a while since I looked at the statistics because I've not been doing this for a while now. But when I was last in this, yeah, the statistics were just a steady increase and then an increase in resistance. And so it's getting to the point where certain STDs are harder and harder to treat. And some of them might eventually become untreatable, or you have to be hospitalized to get a certain really powerful antibiotic to treat it, which is crazy. And so antibiotic stewardship was the whole thing. And so we did that with STDs. And then, I love this conversation. And then we found a fascinating market in sepsis. And so sepsis is a disease that kills hundreds of thousands of people a year. It's basically where you get bacteria in your bloodstream. And what kills you is not actually the bacteria. It's your own immune system. So you're not supposed to have bacteria in your blood, right? Your blood is supposed to be sterile. And when bacteria get in there, your immune system freaks out. And it triggers this whole downstream cascade where your blood vessels start to leak, and all of your organs start failing. And it's basically really bad. And that's what kills you, your own immune reaction to the bacteria rather than the bacteria. And so this is one of the leading causes of death in the US. Often if you're dying from something else, like if you have serious cancer, it'll be sepsis that ultimately ends up being what kills you because you get more susceptible to it with other diseases. And so it's a leading cause of death, increasing mortality. It's incredibly expensive. Outcomes are terrible. And so we were working on basically a better testing technology where, from the earliest date, you could detect these bacteria and what antibiotic they are going to be susceptible to and treat people faster. Because with sepsis, basically every hour that you don't treat somebody is about a 12% increase in mortality. So you want to get the treatment as soon as possible. Every hour you don't treat someone is about a 12% increase in mortality. Yep. Okay. And so we started this sepsis testing. So, started the sepsis testing. And so this- Does it instantly go well? No. So this company died at the end of 2019. Oh, I'm sorry. Yes. So we went to, the testing was working great. Prototypes were pursuing the FDA approval process. We went to do a series B round with what ended up being a strategic- And it's still the same company as this milk table. Same company. Yeah. It changed its name from TL Biolabs to Shield. Oh, I love it. Yeah. Good single name. Okay. So we go to raise the series B. Bigger TAM, sepsis, death, more- Bigger TAM. Gravitas. Yeah. Many, many billions of dollars TAM for testing for this, and ended up getting a term sheet from a strategic, large public diagnostic company. Signed the term sheet, did three weeks of work on docs. We were in the second round of docs. And then their CEO killed it because it was too competitive with their core products. Meanwhile, we told all the investors that, oh yeah, we've got the lead. We're good to go. Here's the paperwork. And so that was the death of the company. We had about three weeks' worth of cash. Would you be where you are today, though, if that round had come together? No, no. Because I don't think we would have pivoted as hard into COVID when COVID hit. It would have probably been easier because we had, at that point, a lab license. So in the US you need this thing called a clear license to run these kinds of tests. And we had gotten one of these licenses over a painstaking two-year process. And then in December of 2019, as part of the wind-down, I sold that license to a company in San Diego for $150,000. to pay some of the creditors. And then five months later, acquired a company in Southern California to get the same license for $27 million. So timing is everything. Whoa, whoa, whoa, wait, wait. So we're winding down the company and we sell this license for $150,000. Which is roughly its market value if there is not a pandemic. Totally get that. Cool. Okay. And so we're winding down the company. The company shut down. I want to go chronologically because that's wild. Shutting down the company in 20, now 20, I guess. It was, yeah, right at the end of 2019. Okay. End of 2019, shutting down the company, strategic, a la Pubelle, fucked that. Yep. And then what happens then? So then I was looking at what to do next. Were you personally devastated? This is five years of your life. Yes. Any lessons for founders, reflections on that? I think it's a lot easier to build a company the second time around. There's so many mistakes the first time where you don't know how to do thing X, like the first time you fire somebody, how to build a good interview process, how to build a pipeline. There's so many things that it's really easy to screw up the first time around. And then when you've seen them go wrong, it's so much easier to build it the second time around. And so yes, it's the worst thing in the world to go through, having something you poured all that time and energy into, and the seven-day work weeks and the late nights basically go to zero. But as long as through that you learn, and you take those lessons and you go solve an even bigger problem, I think you got something out of it. Okay. And so this company is winding down. Yeah. Need to find something else. What happens now? Yeah. So originally the pitch behind curative was we were going to also solve sepsis, but in a completely different way. You really focused on sepsis. Yeah. Yeah. So when we were going through all of this work with the sepsis diagnostics, one of the things that kept jumping out in the data was when you look at other companies that had tried to do sepsis diagnostics, because we were not the first. A bunch of big pharma companies like Roche spent a couple hundred million. Siemens spent a hundred million. A bunch of companies spent a lot of money trying to make better sepsis diagnostics. So it's this graveyard of dead sepsis companies. And when you dig into the data, you find this really interesting thing, that in academic medical centers, when you try out these new sepsis tests, they work great. Yeah. Need to find something else. What happens now? Yeah. So originally, the pitch behind Curative was we were going to also solve sepsis, but in a completely different way. You really focused on sepsis. Yeah. Yeah. So when we were going through all of this work with the sepsis diagnostics, one of the things that kept jumping out in the data was when you look at other companies that had tried to do sepsis diagnostics, because we were not the first. A bunch of big pharma companies like Roche spent a couple hundred million. Siemens spent a hundred million. A bunch of companies spent a lot of money trying to make better sepsis diagnostics. So it's this graveyard of dead sepsis companies. And when you dig into the data, you find this really interesting thing that in academic medical centers, when you try out these new sepsis tests, they work great. And you see much better outcomes, and you see people live longer, and it's saving lives. And then you try to replicate that in bigger studies, and they fail. And when you dig in and look why, it's when you expand that aperture of who's in the trial out of the academic medical center and into community hospitals. What's happening in a community hospital is they're so understaffed. They're so overwhelmed with the volume, particularly in the emergency room. They don't suspect sepsis fast enough. And as I said earlier, every hour is a 12% increase in mortality. And the intervention that they have to do is actually pretty severe. They put a big IV line, usually in your femoral artery. They're pumping you full of fluids. They're pumping you full of NAST antibiotics that have bad side effects. So it's a pretty aggressive treatment. But if they don't suspect sepsis early enough and jump to that treatment, by the time they get there, it's already too late. And so if you're in a community hospital and it's 2 a.m. on a Saturday, is there someone on staff that actually suspects sepsis early enough, or does it wait until Monday morning? And so it doesn't matter if you have a better test if no one ever runs it. And so the original pitch behind Curative is let's take the learnings from an academic medical center and go out to community hospitals and build a mini hospital in a hospital that just manages their sepsis patients. So whenever they get somebody, we will diagnose them as having sepsis out of the emergency room. We will then take on that patient. They will pay us a fixed fee. So no matter what happens, we're on the hook. If we can drive a better outcome by applying mostly just getting doctors to follow the instructions, but at scale, then you could drive better outcomes by getting those academic medical center type clinical results, but helping a community hospital actually do that. So what happens then? We start that business. Start that business. We raised a million dollars of seed money. Justin was the first investor. You mentioned at the beginning, Justin Mateen. He came in right as I was shutting down Shield. He was an investor in Shield, and he wanted to put more money into Shield. And I said, no, I don't think you should do that. I think that company is not going to make it, unfortunately. But I'm thinking of starting this new thing. And he was like, yes, I'm in. And he didn't even know what it was. How much did he put in? He put in, I think, $125,000 at a $3 million valuation. Wow. So he was the first money in. First money in. Love it. And so we had a pilot set up with the first hospital in Wisconsin. This was a clinician that we'd worked with before. He was really enthusiastic. And then we got a call from his assistant saying, this is all on hold, and I can't speak to you for at least three months. Huh. And we were like, that's really out of character, that he wouldn't at least call us or text us, or that he's having his assistant. And when we dug in, they were getting ready for this thing called COVID-19 that they were expecting to see the first patient in their hospital. And so that was the first inkling for me of, oh, crap, this is going to be a big thing. This is going to be bigger than people think it is. And so they were shutting down the entire hospital. And so it started off for us as, okay, well, we can't run our clinical studies. We can't actually launch this product because all the hospitals are in lockdown. Maybe we can go help out with this testing thing for a couple of weeks until all of this blows over. And then we'll go back to sepsis. And so at that point, we're like, we've moved into COVID-19 testing. Yes. Yes. And so it all happened quite quickly from a lot of me saying, no, no, no, this is not going to be a thing. Don't worry about it. What was the moment where you realized, where were you like, this is substantially going to be a real thing? So I was in my apartment in San Francisco looking at some data that I think was on Twitter. And I was like, oh, crap, if this continues at this rate, this is going to be way more substantial than people realize. And so this was probably mid-February. And so then I started to reach out about setting up testing capacity. Well, first of all, we had the problem of finding a lab license because I just sold the lab license. This was 150 grand you just sold. Just sold the lab license. And so we didn't have a lab anymore that was capable of running these kinds of tests. We had a test. So our chief scientific officer at Curative had, in his spare time, developed a COVID test. And one of the things they'd done at a previous company is they developed one of these flu tests and just offered it to employees to make them feel better. And so he said, hey, can I develop a COVID test? I don't think it'll be very useful, but it might make our employees feel good. And it's a good training exercise for the team. And so they had worked on, through January and the early part of February, a COVID test that they'd been developing basically in their spare time, in evenings and on weekends. And so then when everything started to really take off, we actually already had the test. What we didn't have was a lab to deploy then. And so at that point, you then go back to the old one and buy it for 27 million? No. So I bought a different lab license. You bought a different lab license. So we reached out. I reached out to a bunch of people I knew in the Bay Area that had facilities with this kind of license. Nobody wanted anything COVID related on site. Nobody wanted anything to do with it. And so I put it out. I just put out an email to everybody I know. And there's actually a guy who was in the same YC batch as me who had become a VC. And he connected me to a group in LA, and they had this license, and they were using it for sports doping testing. And they were in what I thought was LA. I remember telling Justin, oh, Justin, I'm going to LA. I'll be in San Dimas. And he was like, where the hell is San Dimas? It's basically very far east of actual LA. It's still in LA County. It's a little city, best known for Bill and Ted. It's a little town of 30,000 people. And that's where the lab testing was. And that's where the lab was. And so I flew out there to look at that lab. This was from San Francisco. And to look at one other lab license that was, I think, affiliated with one of the universities. And they had a good space. They had this license, and they were doing pretty minimal testing. So they were just kind of a blank slate. And so it started off as a 50/50 JV between Curative and this company that had the lab license. And we would bring the test. We would bring the expertise. They would bring the license. And it became pretty clear quite quickly that they didn't have the expertise to scale it up. They were actively getting in the way of scaling it up. And so we bought them out. And that was the 27 million. So that was the 27 million. Where did you get 27 million from? Forward revenue from customers. So we were getting paid. We had our first testing contract. We were doing the police and the fire department. I'm sorry. How do you do that? You have the chief science officer who's created this brilliant task here. Yep. And you go to San Francisco state or government council. So this was mostly, yeah. And so actually our very first customer was the sheriff department in San Dimas. Well, we did some private testing for individuals that were paying for the tests. But our first government customer was the sheriff's department in San Dimas. And that came about because they got wind that we were setting up a COVID lab because people Like they were actively getting in the way of scaling it up. And so we bought them out. And that was the 27 million. So that was the 27 million. Where did you get 27 million from? Forward revenue from customers. So we were getting paid. We had our first testing contract. We were doing the police and the fire department. I'm sorry. How do you do that? You have the chief science officer who's created this brilliant task here. Yep. And you go to San Francisco state or government council. So this was mostly, yeah. And so actually our very first customer was the sheriff department in San Dimas. Well, we did some private testing for individuals that were paying for the tests. But our first government customer was the sheriff's department in San Dimas. And that came about because they got wind that we were setting up a COVID lab because people were freaking out about it in the town. And so one of their sheriffs reached out to me on LinkedIn and was like, hey, what are you guys doing? And so I connected with him and I explained what we're doing and how it was very safe and how we had this way of deactivating the COVID as soon as it went into the sound pool. And so there was no live virus on site and we were not presenting a risk to the community. And actually this was going to be a good thing. And we're going to be hiring a lot of people and got him on board that we're doing, we knew what we're doing and we're doing this in a safe way. And then he was like, well, we really need testing. And then the fire department wanted testing. And then our first really big contract was the city of LA. And that came about from a tweet. So we had Laura Deming. Yeah. There was a, you know. Yeah, I remember. She's YC. She's a longevity. Exactly. So she was a friend and was trying to help with the pandemic. And so she actually drove me down to LA with a car full of PCR machines. So I could work on a laptop, and she helped with a lot of the early development work. And she tweeted, hey, we've got COVID testing capacity. Does anybody want some? And the deputy mayor of LA slid into her DMs and was like, yes, please. We would like to talk about that. Wow. So that was how our first big contract came about. And so you speak to the deputy mayor of LA. Yeah. And then, so they were doing a pilot. They said, look, we've got a couple of labs. You're going to have to demonstrate this because we were complete unknown. Right. We'd done. And COVID wasn't peak ramps now, was it? This was early. This was like early March. So people locked down had just started. Everybody was starting to freak out. There was basically nowhere to get a test. Unless you were ultra high risk and in a hospital, there was pretty much no chance you were getting a test. And so everybody was freaking out. This is when everybody was still cleaning their supermarket bags with wipes and nobody knows what's going on. Everything shutting down. It wasn't so bad on the West Coast, but New York was really bad already by this point. And so they're paying ahead of time. So the best thing we could get with the city of LA, because they have obviously, they're a city, there are certain restrictions, is that they would pay after delivery, but they would pay net one on the invoice. And so we would deliver the tests for a day, and then we would send somebody to City Hall the next morning to pick up a check for those tests. Wow. So the tests had been done. They were paying after we delivered them, but it was not your standard net 30 or net 60 for a government contract. They were having, we were invoicing them every day for the number of tests they did. And they were having somebody in their finance department get us the check because we needed that to pay for supplies to basically grow out that testing capacity for where they want it to be. What's the single largest contract you signed? Probably one of the Florida contracts was maybe the largest. So we did a contract with the state of Florida for all of their nursing home testing. I forget what the dollar figure was, but it was in the hundreds of millions of dollars. And so we were, they put it out to bid and we won it. Hundreds of millions. Yeah. But they tested every employee at every nursing home across the state once a week for a three month period. And so they did a great job of basically keeping things open, keeping these nursing homes open, keeping visitation, but making sure that the employees of those nursing homes were not spreading COVID to the people in the nursing homes. And so they wanted to test every single employee that was working at those nursing homes, and then exclude the people that had COVID so they weren't exposing the residents there. And so we ran this big program. A bunch of labs, or they put it out to bid, and everybody said, no, that's too crazy. Like that's impossible. We cannot possibly test that many facilities with that tight a turnaround time. This is impossible. And we've been like, yeah, we can, we can do that. We'll make that work. And we delivered it. What did you see that others didn't? That you have to scale something like that up from scratch. That the existing labs, the lab industry in general, is a very low margin industry and it's built on efficiency. You look at the big labs, the Quest and Lab Corps, and they are ultra efficient machines. Some of what they do with automation is incredible. But if you're asking them to 10 X capacity, that's literally the opposite of what they're built for. They're built for, we will get 1% extra margin by optimizing this bit of the process over here so that it is perfectly efficient. And they're really good at that. But if you ask them to 10 X that, it really doesn't work. And the mindset isn't there. The people don't know how to scale these kinds of things up. All of the supply chain broke down. And so we basically said, okay, start from scratch, throw all of that away. Imagine that you're going to have to scale this up to hundreds of thousands of tests a day. Where do you start? And so we built what we called an orthogonal supply chain, which is just basically a fancy way of saying we don't use the things other people use. You sound like a McKinsey consultant specializing in innovation. An orthogonal supply chain. Yeah, great. Well, I found that was a good fancy word that was helpful from a sales standpoint. Rubber stamp tick. Right. What it basically means is everybody was chasing the same consumables, the same supplies. Everybody was trying to use the same stuff. And if you can make 1 X of that, maybe they can increase to make 1.2 X. If everybody's trying to buy that, us also trying to buy that doesn't help. That doesn't net increase the number of tests being done. Right. It just makes us all squabble over it. So that's pointless. So you got to find other ways of doing the testing using supplies that maybe wouldn't traditionally be used for this kind of testing. So we were sourcing swabs from other types of vendors that were being used for electronic testing and then sterilizing them. We were sourcing, there's this kind of extraction material that you usually use, and magnetic beads is the default standard, but there's this other way of doing it with filter plates, which is more scalable because it's basically just glass and plastic. And you can scale that up faster than you can scale up magnetic beads, where they all come from basically two factories in China. And so we're like, okay, well, we should never use magnetic beads because that's not going to scale as a technology. We need to go find vendors who can scale up the plastic and glass manufacturing and partner with them to basically 10 X it. And so you approach every single bit of the supply chain that way. You end up with this massive scale. Now outside of a pandemic, that doesn't work because people don't want 10 X more testing than they wanted yesterday. But within a pandemic, you got to approach it. And so we peaked, I think our peak day was 206,000 people tested in a single day. 206,000 people tested in a single day. And that was December of 2020. So that was within eight months, from zero to 206,000. And the company went from about seven to 7,000 employees in those first nine months. 7,000 employees in nine months. Yeah. Yeah, it was a little crazy. Do you sleep at all? I don't sleep very much now. But in that time, what was the craziest thing that you did? I mean, some of the hiring, you have to get licensed people for certain roles, You end up with this massive scale. Now, outside of a pandemic, that doesn't work because people don't want 10x more testing than they wanted yesterday. But within a pandemic, you got to approach it. And so we peaked. I think our peak day was 206,000 people tested in a single day. 206,000 people tested in a single day. And that was December of 2020. So that was within eight months, from zero to 206,000. And the company went from about seven to 7,000 employees in those first nine months. 7,000 employees in nine months. Yeah. Yeah, it was a little crazy. Do you sleep at all? I don't sleep very much now. But in that time, what was the craziest thing that you did? Some of the hiring, you have to get licensed people for certain roles, but other more administrative roles, you don't need licensed people. And so we would literally, a lot of people wanted to work on the pandemic, which is very helpful. We'd have people line up in the parking lot, socially distanced, down the street, and then give them five-minute interview slots and just have somebody sit there with a clipboard. And it's five minutes and next, just to get the volume of people in the door. How much money did you make from COVID testing? I think the total revenue ended up being about 5 billion over a three-year period. Five billion. Five billion. Is that the largest private provider? We were, yeah, we were the largest non-Lab Corp and Quest testing company. That is extraordinary. What is the margin profile on a COVID test? So really good during surges and then really bad not during surges. So what we found was when there was a peak, right? So we get a new variant, or this usually winter was the biggest peak, but then we started having these summer peaks, which was weird. Everybody would run to get tested. And these were all public testing sites. So these were in parking lots. These were the drive-through tests. That was what we were doing. So if you went to a drive-through testing site, the biggest one was the Dodger Stadium site in LA. It was seven lanes of traffic, 7 AM to 7 PM, seven days a week. So they were testing, at the peak, about 10,000 people a day coming through in their cars, getting tested, and coming back to the lab. So when you're at peak capacity and you're filling all of the lab's volume, it's very profitable. Then those surges subside, right? And you end up back at testing, using 20 or 30% of your capacity. All your fixed costs are the same. You're still paying 7,000 people. Now, you don't have to buy as many consumables, but all of that infrastructure has to be maintained for the surge. And so this is, again, where it's the opposite of the traditional lab industry, where they have a very flat volume. Every year, people do roughly the same amount of blood work as they did last year, or maybe they do predictably slightly more, but it's within a couple of percentage points. Here, you're building it for that peak capacity, and then during the lulls, maintaining that capacity is incredibly expensive. And so it was necessary. And this was part of the way it was set up. They increased the reimbursement price that they were paying for these tests because they needed to incentivize the capacity to be built. Because if you don't build that peak capacity, then when you have a surge, it all goes horribly wrong and no one can get a test. But that means you basically have to pay to overbuild it because during the dips, you have to have that capacity. You can't just shut it down, right? And you can't build up 7,000 in 24 hours. And so you need to maintain that. And so we would lose a lot of money in every one of the dips, basically. Well, you'd actually lose money. Yeah. Yeah. Yeah. We would lose money on every test during the dips. Oh, wow. Yeah. So of the 5 billion, how much is profit? So after all was said and done, the money that we basically put forward into the insurance business, the health insurance company, was about 500 million that we invested into the health insurance business. It's absolutely astonishing. Yeah. Can I ask you, when we saw the vaccines roll out, did you know they were ineffective in the way that they've turned out to be? It was not clear at the beginning. And I think also it's changed, in that when nobody's had any exposure to COVID, being vaccinated probably provides a lot more benefit. Once everybody had COVID a few times, then the vaccine's benefit is much less because you've already had it. Also, the variants got weaker and weaker. When we were first rolling them out, I think in December of 2020, there was benefit for a lot of people getting the vaccine. Did you get vaccinated? Yes. We did that. We did two and a half million vaccinations. That was another service we did. We also lost a ton of money on that. That was a terrible business. Why? Because the government wasn't paying enough. We lost money on every single dose. It cost more to administer them than we were getting paid. So why did you do it? Giving back. A lot of our partners wanted it. So a lot of the partners on the government side we were working with for testing also wanted us to administer vaccinations. Was it, that sounds awful, was it hard, your business with COVID obviously being eased? Yeah. Completely changes. And you have to pivot again. Yeah. So that started very early for us because I was convinced this wouldn't last very long. Were you always aware it wouldn't last? Yes. When we started hiring people at the beginning, we told them this is three months. You have a job for three months. Don't bank on anything beyond three months. This is a three-month gig, and we're going to shut it all down in three months. So the CFO, and now the president of Curative, joined at the beginning, and for her it was going to be a six-month gig. She came out of retirement to help with the pandemic for six months. And now, six years later, she's still here. But it was supposed to be temporary. And every time a surge, we got through a surge, I was like, all right, that's it. It'll be over now. And then they just kept happening. So we started looking at what comes next in the middle of 2020, really early. How did that search for what comes next change? You just started looking in the middle of 2020. It's not until the end of 22, start of 23, when that actual search is activated into a real-time plan. Correct? Yeah. I think we started probably late 21 is when we got really serious about health insurance. It just took a while to actually get the license. Yeah. Why health insurance? Well, it wasn't the first idea. We looked at a bunch of other stuff. We looked at other stuff in the lab testing industry. Unfortunately, it's just not that big an industry. And so even we had this interesting technology that could theoretically let you do a lot of lab tests that are individual tests today as just one single test, which would be scientifically quite cool. But even if you say, okay, I'm going to displace all of LabCorp and Quest, that's about 30 billion of market cap. So that's the largest company you could possibly build, is about 30 billion, which is a big company. But coming out of what we did with COVID, I wanted to build a much bigger company than that. And so there's just not a big enough market in lab testing. So the lab testing was out. And then we briefly looked at trying to buy a hospital or multiple hospitals. We looked at one in Florida and we looked at one in Texas. And the idea was, well, if the hospital is the whole health system becoming the center of where care is delivered, they have bought up a lot of the primary care offices. If you can transform that with technology, can you drive much better outcomes? What we ultimately decided is it doesn't work that well because the payer mix is too broken up. And so as a hospital, your customer is 50% of the government and then a whole bunch of split-up smaller insurance plans. And they all want different things, and they change their mind every five minutes about what they actually want. And you're trying to keep them all happy. So your ability to really change things from the hospital side is quite limited, is what we ended up deciding. And when you come back to it, we looked at a bunch of preventative care things. We looked at a primary care chain. Everything ends up coming back to the payer. The payer is the one that drives behavior in the US healthcare system. center of where care is delivered, they buy it, have bought up a lot of the primary care offices. If you can transform that with technology, can you drive much better outcomes? What we ultimately decided is it doesn't work that well because the payer mix is too broken up. And so as a hospital, your customer is 50% of the government and then a whole bunch of split-up smaller insurance plans. And they all want different things, and they change their mind every five minutes about what they actually want. And you're trying to keep them all happy. So your ability to really change things from the hospital side is quite limited, is what we ended up deciding. And when you come back to it, we looked at a bunch of preventative care things. We looked at a primary care chain. Everything ends up coming back to the payer. The payer is the one that drives behavior in the US healthcare system. If you are providing the dollars, people will go where the dollars are. If you say, I'm going to pay for this service, people will go do that service. If you say, I'm not going to pay for this, people will stop doing that. And so the payer is the one that's driving things. If you could do one thing to change the structure of the US healthcare system today, magic wand, what would you do? I think you have to break up the negotiating into smaller units. It's gotten to this point where I think it's quite an efficient system as a market when the counterparties are small. When everything gets very consolidated, it becomes incredibly inefficient. So when we look at, for example, health systems, right? So we pay for care at health systems. Some of that care you can get in other places. If we look at how much we pay a primary care doctor who's independent compared to a primary care doctor affiliated with a system, affiliated with a system, they get paid an average double. Same service, same credentials. It's just that this one is part of a hospital system. And that hospital system will use the fact that they have a ton of beds, that they have this ultra-special surgery center that you need. We need to have that capacity in our network because some people need to be hospitalized. Some people need those services. If you want to get access to that, you've got to pay me double for my primary care doctors. And so when all of the players are small, when you have smaller payers and smaller hospitals, you end up getting to reasonable negotiations. What's happened is you have these massive payers, the market is ultra-consolidated. You have four large players that control the entire market on the payer side. And then you get these ultra-consolidated hospital systems because that's the only way for them to survive. If they want to fight with Blue Cross, the only way to survive is to get really big so they have the negotiating power. And then they just reach these loggerheads where nothing gets done, and everybody's overpaying for everything, and everything's inefficient. And when you have more competition in the market, more smaller payers entering, more smaller health systems, you start to get into the market. You get an actual efficient market when you're just negotiating for, hey, I have a third of healthcare in the state and I have a third of all of the employees in the state. It's not an efficient market anymore because there's no alternative. You must reach a deal. If I am sick, is the best place to be treated in the US? Yes, definitely. Seriously? Yeah. Yeah, the US has access to by far the most cutting edge. So I think that's a lot of people who are going to spend more than a lot of money. And they are willing to spend a lot more. What do you know now, sorry, that you wish you'd known when you made the pivot into insurance? I think I wish that new AI was coming. Because I think the way we designed the business in 2022, when we first started, we had no idea that this wave of AI and LLMs was coming. We were building a health insurance business because we thought it was a good business to build. And we thought it needed to be built. We needed better alternatives in the market for health insurance. And then in the last 18 months, how we do pretty much everything is now a completely different workflow. And there's so much, I mean, all health insurance does is moving bits around, right? We don't have a physical product. We give you a little plastic card, but apart from that, our product is that we move bits around in a database that means care is paid for. That's it, right? And we do a lot of managing a marketplace. We work with the providers to negotiate prices. We work with employers to negotiate how much they pay. And then we try to work with employees to keep them healthy. If we can get people to stay healthy, we can avoid the long-term downstream cost of care. But essentially it's a marketplace business. And that has been fundamentally shifted by AI. But when we first started building, we didn't know that was coming. How's it been shifted by AI? So much of that back-office work has been completely changed by AI. We now have entire departments that used to be people rubber-stamping things. The first one that went to zero people was our credentialing department, where this is a process that's incredibly labor-intensive, where you have to check all doctors that join our network have a valid medical license and aren't being sued for malpractice. And this is a person going to the medical board website, checking that the license record is there, checking transcripts from their school, checking a database of who's been sued by who, and then rubber-stamping. And that used to take us two to three months on average and cost about $50. We have now built in-house an agent that runs on Claude that does this end to end. And it goes to the website. It verifies the license. It goes and reads the transcripts. It puts it all together. It stamps it for approval. And we're now averaging about 12 hours turnaround time for credentialing somebody. And it costs us about 20 cents. And so this is a mind-numbing process that payers have to do, which is important. We want to know the doctors in our network are validly licensed to practice medicine. But it historically has always been terrible, and payers have been bad at it, right? If you're a doctor and you join a network and it takes three months before you can see any patients, it's just bureaucracy, right? Doctors hate that. And it's not actually adding the value that it should be adding. It's just creating paperwork. How many people did you have in credentialing? That one wasn't that large. I think there were five or six people. We had a few other departments that have shrunk more than that with that. What other departments? We've seen a lot on the claim side. Claims processing used to be a very manual process where claims come in and people manually tweak and edit it. And also on the underwriting side. Underwriting, the process used to be a broker comes to us with a group, an employer that they're looking to insure. And they ask for competitive bids from multiple different insurance companies. And what that means is basically sending us an email with a bunch of PDFs and spreadsheets attached of who are the employees, what current claims do they have, what's the current insurance look like. And you'd think that over time they would develop a standardized-ish format for how that should run. But no, every single one is a different spreadsheet format, different PDF. And we tried to solve that problem with software and build universal importers and universal intake. And it kind of works, but what we found works amazingly is literally to give the files to an agent, tell it to write Python to get these files into a standardized format. Because they're not very good at parsing files, but they're incredibly good at code gen. And so you can tell it to write a Python script to convert any random file into this known format and then test it and loop and iterate on your script until it's working. And then you throw away that script. And so it's single-use code that never gets used again. You just generate that code one time and then throw it away. And that works so well. And so now brokers, providers, employers, when people are sending us files, we always used to insist, oh, you have to use our standard format for this. And they would hate it, and they'd get mad because somebody was sitting there in a provider office manually reformatting these files into our spreadsheet. Now, send us whatever you've got, whatever format. It can be scribbles on a napkin. It doesn't matter. The model will figure it out. The model will convert it into our standard format. It will do it in about 15 minutes. And so you build these data ingestion pipelines that used to be hundreds of people sitting, moving spreadsheets around. And then you throw away that script. And so it's single-use code that never gets used again. You just generate that code one time and then throw it away. And that works so well. And so now brokers, providers, employers, when people are sending us files, we always used to insist, oh, you have to use our standard format for this. And they would hate it and they'd get mad because somebody sitting there in a provider office manually reformatting these files into our spreadsheet. Now, send us whatever you've got, whatever format, it can be scribbles on a napkin. It doesn't matter. The model will figure it out. The model will convert it into our standard format. It will do it in about 15 minutes. And so you build these data ingestion pipelines that used to be hundreds of people sitting, moving spreadsheets around. And it's now a model writing Python code to do that same thing. And then every single time you throw that Python away and start from scratch. Dude, I have so many questions to ask on the back of this. The first one is you mentioned the internal agent build-out that you've done for the company and for your specific processes. Do you buy the SaaS is dead theory that we will? Yes. Why? Because I see the number of contracts we're canceling. We just recently canceled our Salesforce contract because we have an internal CRM that was built, was vibe coded, that is working better, that is managing our process better, is more integrated into what we're doing. We run our agents inside of it, and no one was using Salesforce anymore. $600,000 a year. Wow. Gone to zero. How long did it take? Two months. Is it worth, because argument back, I always like to do both sides. I'm never. Yeah, yeah. Is it worth the engineering hours to vibe code that and then to maintain it? The maintenance is definitely one of the most challenging pieces. I agree with that. I think for most businesses of any reasonable scale, yes, it is worth it. Now, whether they will have the tech resources to do that soon, I think that's the bigger question. It's when will this happen? It's when will this happen? But when you build those things custom to your workflow, they work better. Most of these big systems, you're paying an administrator. We had a full-time Salesforce administrator. Right? You're paying people whose sole job is to manage this archaic software platform. Not that Salesforce is archaic, but we have a few other internal apps that we were paying for, industry software that is taking multiple FTEs to maintain. You can transition that into one great engineer. And then whenever you want a custom feature, you just go build it. Absolutely fucking wild. $600,000 a year on Salesforce. Yeah. Wow. And so we're seeing, there's pockets of software that I think persist because they are more infrastructure-based. Okay. Which persist? So we're seeing a lot of back-end stuff, like Sentry, stuff like that, right? Where it's become part of your infrastructure. Slack has been notoriously hard internally for us to, too many, so many people have built integrations and workflows that are now working in Slack. I think that while they keep putting the prices up, if they put the prices up too much, then eventually it'll make sense to replace that. But what else is on the chopping block? We were cutting about 80% of our SaaS spend this year. Wow. So we had, in one of our internal meetings, a slide of when are SaaS contracts due and whose job is it to tell them that we're not renewing this year? Well, you can do it in one fell swoop. Yeah. Well, they have renewals. We have to pay them through the renewal. Ah, is it all legacy software like Salesforce? Some of it's like that. Some of it's very insurance-specific software. So our claim system, for example, is this massive off-the-shelf platform that we just migrated to a few years ago. This is again why, if I'd known AI was coming, we would probably approach things differently. And it's very hard to use. Their API barely works. It's hard to get the data out of their database. They won't let us manage it. But that's how insurance companies are running things. And so we've built our own claim system completely from scratch in-house. We've migrated most of the workflows off. We'll be fully off in July. I am a health insurer. You know other health insurers. Yes. I do not have the in-house capability potentially technically to build the agentic workforce that you are building. Yep. Am I screwed? I think some of the biggest insurers will struggle. Because they will not be able to keep up from a margin standpoint with where we can get to with agents. I think some of them do have technical expertise. It's more operational and people ops. If you've built a company of a hundred thousand people and in order to get this margin improvement, 50,000 of them have to be laid off, somebody's fiefdom just got a lot smaller. And so they will do it slowly over 10 years. It will happen, but will it happen quickly? No. And will we be able to compete more effectively in the meantime? Yes. How do margins change? Insurance is a very low-margin business. So 85% of your premium that we collect must go out the door to pay for care. So if we get in a dollar, we got to spend 85 cents. I have to. By law. If less than that goes out the door, we have to give it back to the employer. Which is another thing that's broken about U.S. healthcare, because that drives completely the wrong incentive where actually from an insurance company standpoint, if your profits are capped at 15%, the only way to increase profits is to increase total spending, which is not what you want your insurance company incentivized to do. Why would I encourage people to go to the gym, eat healthily, if actually I'm not going to get that back anyway? So this was part of Obamacare, and it's one of the, there's a lot of good things in Obamacare, but there were a lot of things that I think the second-order consequence was not considered. It sounds like a great PR thing to say we've capped insurance company profits, right? That sounds good, but it's BS. It's like capping CEOs' base pay sounds great. Yeah. So let's just pay them 27 million in equity compensation. That's the reason why we have such egregious comp packages for execs. Because they cap the salary pay. Yeah. Ridiculous. With that, how have your Anthropic costs gone? Yes. So, I mean, this is one of the leading indicators for us, that our Anthropic cost over the last six or seven months has 6x every month. From a base of a couple of tens of thousands of dollars, now up to millions of dollars a month. And it just keeps, eventually we're going to have to stop that spending increase because it'll get unreasonable, but we just keep finding new things to do with it. And then the other thing we found that's been fascinating, we're seeing a lot of areas where it's not that we are necessarily replacing the team. It's that we're repurposing the team, and they are now so much more productive. And so one area that has always been a particularly challenging thing that makes it hard to build a new insurance company is we have to build this network. So the network is all the doctors and all the hospitals and all the people that we have to contract with. And there's about 1.2 million of those in the U.S. that you want to have contracted. That ends up being 60, 70,000 contracts that you have to do. That's just a lot of work to go out, get their attention, do a negotiation, get them to sign an agreement, load all of their data, and have them in your network. And this has been one of the biggest pieces of staying power of the big health plan businesses, is they built that over 100 years for Blue Cross and over 50 years for United, Cigna, and Aetna. And so they did it slowly over a long period of time. If you're trying to, from scratch, come in and start a new health plan, you've got to reach out to all of those doctors and negotiate. And so we have a team of about 45 people who do those network contracts, and they reach out and they negotiate. What we launched earlier this year is an agent called Gwen. And Gwen does the same workflow. You give her basically a lead. Hey, there's a primary care office over here. Here's the address. That's just a lot of work to go out, get their attention, do a negotiation, get them to sign an agreement, load all of their data, and have them in your network. And this has been one of the biggest pieces of staying power of the big health plan businesses, is they built that over 100 years for Blue Cross and over 50 years for United, Cigna, and Aetna. And so they did it slowly over a long period of time. If you're trying to, from scratch, come in and start a new health plan, you've got to reach out to all of those doctors and negotiate. And so we have a team of about 45 people who do those network contracts, and they reach out and they negotiate. What we launched earlier this year is an agent called Gwen. And Gwen does the same workflow. You give her a lead. Hey, there's a primary care office over here. Here's the address. And she will go Google it, research them, learn a little bit about their practice, figure out what other payers are paying them, because there's a lot of this data out there in these transparency files now of how much they are getting paid. Find their email address from ZoomInfo, reach out to them, and then ping them repeatedly until they answer her, with custom emails. Hey, I know about your practice. I know what you're doing, customized content to them. And then when she gets their attention, negotiate the rates back and forth, usually over multiple rounds of negotiation, negotiate and redline the language. And that's another place where we found Python is great. These models are terrible at editing Word documents. But if you tell them to write Python to edit a Word document, they're great at it. Great hack. And then sign the agreement. So she now signs the agreements with my signature. She'll open up the DocuSign link and then click the button. And it's my signature on that agreement. And so this has taken us from doing about 100 contracts a week to about 100 contracts a day. And last year, as an entire team, we did 2,300 contracts. So far, in about the last eight weeks, the agent alone has done 3,500. And so what this is letting us do is that team doesn't go to zero. We've refocused that team to work on these bigger contracts, right? Because some of these deals we can do entirely over email. This agent is email only. And some of these providers will work completely over email to enter into an agreement. And actually, how many of them will do the whole thing over email surprised me. There's a lot of millennials, I guess, on the other end that don't want to get on the phone and would rather do the whole negotiation completely electronically, which is fantastic because the model is great at that. But some of them, the bigger hospital systems, the bigger doctor groups, they want to have a phone call. They want to meet in person. They want to learn who we are. And the team now gets to spend their time going and having those in-person meetings, going and developing those relationships, working with those bigger groups. And then even when it gets to the paperwork, handing the paperwork off to the model. And then all of the smaller, the individual PCP over here, the small behavioral health provider here, the therapist over here, the agent just gets it done and can sign a contract end-to-end in a few hours, where you wouldn't be able to do that volume with people. Given the transformational nature of what you're describing, if Anthropic doubled their price, would it impact your usage? When we look at a lot of the financials of these core businesses today, they are challenged businesses in their current infrastructure and pricing model. If they double pricing, would it stay the same? If I say yes, I don't want our Anthropic rep to double our pricing. But it would. It would work. It would be fine. Yeah. So it costs, with people, about $1,500 to $2,000 on average to do a contract. The average with Gwen has been about $70. So it would still work fine. And so that's what we've seen, is partly why the token use has exploded for us. Am I being a complete idiot then? But then if they 5x their pricing, if you went on the labor displacement theory, it would still work. It would still work. I think what they're betting, and what also we've seen, is you don't just displace the labor. So here, I think contracting is a perfect example. We've not said, okay, we're doing 100 a week, so we'll get the agent to do 100 a week. What we've done is said, well, now that we have the agent, we can do 10 times as many contracts this year as we could do last year. So we're going to do 10 times, and then we're going to try and do 20 times. And we would just do a lot more volume than you could possibly have done with a human team. And everyone's like, oh, I'll lose my job, lose my jobs. Do you think that's warranted? I think for a lot of these back office jobs, yes. So how do we determine between, I'm just going to do more? Yeah. A lot of people say with developers, we're not going to get rid of developers. There's an insatiable appetite for more software, better software. That side I do agree with. I think- How do we determine between functions where we'll do more versus we'll be replaced? So what we've tried to differentiate at Curative is there are two areas where we're really investing in people. That's technical skills and relationships. Those are two aspects that I don't see going away anytime soon. We still have a team that is actually deploying all of this AI. They use a ton of AI in all of their day-to-day work, right? They're not writing any code anymore. They're not even reading the code anymore. They're deploying all of this with cloud code or codex and seeing incredible results out of one senior engineer now, who is so much more productive than they were a year ago, that we're investing in having those people. At the same time, there's a side, particularly to health insurance, that is relationship-driven that I don't see as going away anytime soon. Ultimately, we insure a member, and that member wants to be able to call and talk to a person. We have a lot of AI they can talk to. The AI is great. They love talking to the AI, but there has to be a person somewhere in the loop. We also work with these provider groups. We have a relationship with that provider group that we're providing a chunk of your revenue. We work with you. You work with us. There's a relationship aspect there that has to be maintained, particularly for the larger groups, by a person. And then on the sales side, we sell through a broker, and that broker wants to have a finalist presentation. They want to go to dinner. They want to go and play golf. And so what we've seen is on the sales side, that relationship is, if anything, more powerful. Do you think they still will in five years? A lot of people talk about agent-to-agent transactions and how that changes the process. Do you think we will still have that heavy relationship interpersonal sell in five, ten years? I think in some aspects, yes. Because I think in some aspects, that kind of becomes the foundation of trust. And it's almost the scarce resource, right? If you want to do a deal that's important, then you're going to use your scarce resource of people to manage that. It's almost like... It's also the bigger the contract. Yeah. The more important it is to have the whites of the eyes and the trust in the relationship. And most of these contracts, right, most employers, even our smallest employers, it's a million-dollar contract at least. I always think that when you look at accountants and lawyers, and a lot of the people who could be replaced in some of the more simple, especially NDAs. But you would never not have a law firm do it because if it goes wrong, they're getting fired. Yeah. Yeah. But I think you'll see it work differently, though, where... What we're seeing with Gwen is we had a contract, a standard template contract, that was drafted by a law firm. And then we have guardrails for what Gwen can agree to. But she just redlines it and then signs it. It doesn't go to a law firm for review. We're signing hundreds of these contracts a day. It would be too encumbering. It would be too slow. And they would just be reviewing it with AI anyway. So we trust the agent to do that legal review within certain parameters. In three years' time, knowing what you do now about the capabilities that you use it for, how big do you think Anthropoc will be? A lot bigger than they are today. Do you think it could be $5 trillion? I think it could be $10 trillion. Bugger fuck. It's just extraordinary, isn't it? Yeah. Because I think you just find all these new things that you can do that you just couldn't do before, that it wasn't possible to do. And then we have guardrails for what Gwen can agree to. But she just redlines it and then signs it. It doesn't go to a law firm for a review. We're signing hundreds of these contracts a day. It would be too encumbering. It would be too slow. And they would just be reviewing it with AI anyway. So we trust the agent to do that legal review within certain parameters. In three years' time, knowing what you do now about the capabilities that you use it for, how big do you think Anthropoc will be? A lot bigger than they are today. Do you think it could be $5 trillion? I think it could be $10 trillion. Bugger fuck. It's just extraordinary, isn't it? Yeah. Because I think you just find all these new things that you can do that you just couldn't do before, that it wasn't possible to do. So Gwen is sending, on average, 15,000 emails a day. Customized emails to providers that know about their practice, that know about their work. And one of the things we found is that relentlessness of the follow-up is what works. A lot of providers will get them on the ninth email. There is no way that a human is going to email them nine times because people, that's, you have to have no shame to reach out that many times. Do you want to hear something funny? You mentioned Salesforce. I got Mark Benioff on the show because I emailed him 53 times, once every week for a year and a week. There we go. Oh, yeah. It works. It works. It's an AI model. I lost my personality years ago. Very effective AI model. That is extraordinary. But that works so well in sales. And the best salespeople will do that. But it's really hard to scale that. And you end up getting people that reach out three times and then give up. Yeah. And when you're trying to scale something up, if you can scale up that relentlessness, that is really valuable. So you fundamentally buy, the companies will be inherently smaller in the future. And that's why we're seeing layoffs. Yes. Are layoffs today just an excuse for overhiring in 2021 and 2022? I think it's a mix. Yeah. I think there's definitely some of that. And it's also companies are seeing valuation boosts by doing it. So that's incentivizing maybe bad behavior. But some of it, for sure, is that these workflows are changing. How big are you today? We're about 650 people now. How big will you be in five years' time? Well, in five years, we'll probably be bigger. In the short term, I think we're going to be quite a bit smaller. Smaller? Yeah. We're not done yet with all of these back-end workflows. How small? Does that go to 400? Somewhere around there. Wow. There's some aspects of the business that are clinical workflows. So all of our members get a care navigator who stays with them for their entire journey. And that is just going to grow linearly with our membership. So we want you to have that human point of contact that is available. But the care navigators are now getting significantly more useful because they can actually use the agents to do a lot of the follow-up on their behalf. And they're not having to remember to reach out to this diabetic member every week about X. They can manage it at a population scale. And so there, we're keeping the same headcount relative to our membership growth, but just letting them do so much more than they could do before. That's amazing. I was speaking to a major airline where they were saying, actually, about exactly that, premium care customer service. They're able to give so much more for your recommendations for you and your wife's trip to New York. And everything's so perfected and tailored because all the bullshit that they used to do is gone. And for you as the end consumer, it's amazing. And the response time, the response time is so much better. You get a response back in a few minutes. That's the usual place where we see people ask Gwen if she's an AI, is when she responds to your email within five minutes. Because in healthcare, if you get a response the same week from an insurance company, you're doing so well. And people think that I'm an AI because I respond very quickly on email. And to the point where I'm like, no, I just have no life. You said about the different data inputs of, oh, you can just send us anything now. I always was like, data cleansing, data structures would be the biggest inhibitor to enterprise adoption of AI. Is that totally wrong bullshit VC? I think if you approach it in the right way, then the cleanliness doesn't really matter that much. Because the models are so good at cleaning up the data if you give them the right context. And so that's one of the things we found, actually, with migrating away from some of these SaaS vendors. We moved away from Looker, Google's Looker product for visualizations. It's super expensive. And we moved to do it in Snowflake. And it's been a lot cheaper. It's worked really well. Part of that migration is moving all of our dashboards, and all of the things that fed from Looker would have taken probably a year and a whole bunch of engineers and data scientists. We did most of it with an agentic workflow that would spin up, find the next dashboard, figure out how to convert it into what we needed, and then close it down on the Looker side and boot it up on the other side. And it ended up being a project for one or two people. And it still took a couple of months, but it was a lot more doable because we didn't have to have somebody ingest or figure out that data. You can just feed that data into a model and let it figure out how to stretch it going forward. It's just really interesting because I often think about what role does not exist today that will be massive in five years' time. And I thought data cleansing would be one of those roles. If I asked you what role does not exist today that you think will be very big in five years' time, what would you say? Agent supervisor? What does that mean? One of the things we've found that's been a bottleneck is when you launch these agent workflows, there's always things that they, you don't want to let it do everything, right? So with our contracting, our sales workflow, there's a certain margin threshold where the sales agent can't promise a client that we'll do it at that margin. But we don't necessarily want it to say no. We want to make a business decision about whether this is the right thing to do for that client. And so you end up generating this massive list of approval requests that is now much longer than it would have been because you're doing 10 times as much work. So you're now getting, even if you're only getting an approval request 1% of the time, you're still getting 10 times as many as you were last year. And so one of the things we found is actually, how do you manage all of those exceptions that now become a really high volume? So we tried agents supervising agents, which I think works to a degree. And maybe as the models get better as well, you can also have a more expensive, right? If we ever get Mythos and it costs $100 per million tokens, you probably wouldn't use it for the core workflow, but you could maybe use it as a supervisor. But how you actually manage those agents at scale with the volume of exceptions that they generate? Because you don't want them just rubber-stamping yes or no either way. You need a more nuanced decision there. If you were advising your younger brother or sister on how to prepare for that role, what would you advise them to do to be adequately skilled to do that? I think just play with the models. I think a lot of people severely underestimate what they're capable of because maybe they'd tried ChatGPT two years ago. They're moving so fast, and they're so much better than they were even six months ago, that if you're not relentlessly trying them, then you're going to significantly underestimate. And then also, where they are today is not where they're going to be, clearly, in a few years. So you've got to skate to where the puck is going to be. Where will they be in a few years? Ahead of humans on most capabilities. Are you excited? Yes, because I think that opens up so many possibilities, unlimited intelligence. Are you not worried about short-term societal unrest, labor displacement, and what that will do to a hollowing out and inequality increase in the US? I think that can be dealt with by significant action, whether or not we do that or not. What significant action would you do to mitigate that? I think eventually some version of universal basic income. Really? Yeah. And you buy that works. I think we have to build the social structures that give those people purpose and meaning outside of work. Because I don't think that we're going to have... And I don't think that's a bad thing. A lot of these mid-level jobs that are being replaced are awful jobs. So you've got to skate to where the puck is going to be. Where will they be in a few years? Ahead of humans on most capabilities. Are you excited? Yes, because I think that opens up so many possibilities, unlimited intelligence. Are you not worried about short-term societal unrest, labor displacement, and what that will do to a hollowing out and inequality increase in the US? I think that can be dealt with by significant action, whether or not we do that. What significant action would you do to mitigate that? I think eventually some version of universal basic income. Really? Yeah. And you buy that works. I think we have to build the social structures that give those people purpose and meaning outside of work. Because I don't think that we're going to have... And I don't think that's a bad thing. A lot of these mid-level jobs that are being replaced are awful jobs. They're people sitting at a desk with fluorescent lamps shining at their face, reviewing random paperwork. That's not what people, when you're little and you say, what do you want to be when you grow up? I want to sit in an office and rubber stamp insurance forms. It's not a good job. I would be worried if my job weren't. Right. So these are not... It's not like you're taking some super aspirational thing away from people. I think these are jobs that we'll look back on and say, God, I can't believe we had people doing that kind of work. That's crazy. I walk with my mother a lot, and I always say my job is to invest in the things that we say, God, I can't believe we used to do it that way. I said, do you remember? I would never put my credit card on the internet. Or you'd never find your husband on the internet. You'd never get in a stranger's car and have them drive you where you want to go. What is insane today that will be incredibly... Obviously, you have your card online. Obviously, you meet your partner online. What is insane today that you think will be like, obviously, in 10 years? I think empowering agents to do things on your behalf. We've seen internally getting the team. I think Isaac, our CTO and co-founder, and I have trusted the agents faster than most of the team. And we're okay giving the agent authority to do things. It was a big internal dispute getting the agent to sign these contracts. So the agent opens DocuSign and clicks the sign button, and it's legally binding, and it has my signature on the page. And getting that figured out internally was very... It took a lot of rounds of convincing people that that was okay and that we can do that. And so I think it will take time for people to trust these agents with stuff like give it your credit card and let it go book a holiday, right? Getting people to trust it acting on your behalf, I think, will take longer. But I'm thrilled that you signed me your house for $12. So there's one vote. Yeah. Do you worry about the concentration of value? When you look at the Mag7 providing 85% of gains year to date in stock markets and then Anthropic, OpenAI, maybe one or two more. Do you worry about that concentration of value? I'm quite bullish now because I think a lot of what's going on in AI is going to massively boost earnings in other areas of the economy that have struggled to grow earnings any other way. Health insurance. Health insurance. How do you grow health insurance earnings? Well, it's been... Or you go chase government business and you pay a bunch of lobbyists to get the government to overpay for care. That's all now backfired, and all the government business, Medicare and Medicaid, is now a bad business, and they're all losing money. Everybody has insurance. So unless you're going to increase the total spending, how do you grow earnings? Well, if you can make it more efficient, so you're not spending 9% of your premium on admin tasks, that's a way you can grow earnings without having to deliver a worse product. You're in a really good business as well because it's unwaveringly not in the path of the model providers as well. Yes. I put it in the... They're not going to start an insurance company. Yeah, I put it in the path of we're big investing in our wallets, which is business banking. Yeah. Anthropic is not going into business banking. Right. In Southeast Asia. I would be surprised. I think things that have some regulation around them and are complex industries, yes, they're going to see the advantages of the models, but they're not going to see competition from Anthropic or OpenAI. I totally get that. When I listen to you, I'm like, Jesus, if I was you, I'd also take a chunk of my money and invest it actively into Anthropic. Can I ask you, have you taken secondaries along the way? No. No, we haven't sold any secondaries. We did. There was a dividend at the end of COVID. We paid out some. All of the investors got 10x their money back before we started the health insurance company, and then they still have their shares today. Wow. We haven't sold any secondaries. No. Are you fucking serious? They got 10x their money back, and then they kept the shares. We didn't have that many investors, but yes, they all did well. That is an amazing deal. 10x, and then you keep the shares. Yeah. What? Well, I think that's why we've seen them double down, right? They made money with us before, and so this last round was led by insiders. And how big was the last round? 150 million. What was the price? 1.3 billion. Wow. Nice round, actually. Excellent. Not too much dilution, enough that it's really impactful cash-wise to come in. Yep. Wow. Dude, that's insane. So can I ask you then, personally, I ask this about you. Do you know Josh Browder? He's another Brit in the Valley. Okay. Phenomenal guy. But when you look at your personal allocation today, given our insider access and what we know, is there anything funky that you do with your money? Outside of Curative? Yeah. I invest primarily in companies of people that I know, and I do very little investing if I don't know the founders. Does that work well? It's had mixed results, but some of them are too early to tell. Best investment? They're all a bit too early to tell. Do you have any energy investments? Yes. So there is a company that I co-founded with my wife, Subcritical, that is in the nuclear fission space. So this was based on an idea that I had a few years ago that we need more power and that nuclear is a really good way to do this. And it started off actually looking for an investment. This was one of my first times I was like, we should find a company that's doing nuclear power and try to invest in it and see if we can make it go faster. Because I thought, I'm pretty good at making things go faster in really regulated spaces. That's what I'm good at. That's your thing. Yeah, that's my thing. Yeah. Everybody's got to have a thing. Is that your hook on the first date? Regulated industries, I make it go faster. Well, the hook on our first date. So after our first date, we both shared our genome files with each other, our VCF. And so she said she'd done this before and the guy thought it was really strange. And we both were like, oh, we should share our genomes. And then compared and checked that we were compatible so that it was worth having a second date. And we were both totally into that. So we knew it was meant to be. We were compatible by genome. We have two beautiful kids. So we knew it was meant to be. I'm sorry. If you were incompatible by genome, you have like a... If you both have the same... You have a ginger child? Well, that was a concern. My brother is ginger. I'm sorry. So I carry the ginger gene. My brother is ginger too. Yeah. Yeah. We don't see him anymore. We took him to the woods and said run free. Makes sense. Yeah. So I do carry the ginger gene. And if she had carried the ginger gene, that would have been a deep concern. But she luckily doesn't. And so that was one of the key tests. You progressed to the second date. Yes. So we made it to the second date. What does no one know about nuclear that everyone should know about nuclear? That it is very safe. I think... And that it's not a science or engineering problem. When we started looking at companies to invest in, that was, for me, the thing that I was disappointed by, is everybody was approaching it as if nuclear is this massive engineering challenge. And sure, the engineering is hard. It is complicated. My brother is ginger. I'm sorry. So I carry the ginger gene. My brother is ginger too. Yeah. Yeah. We don't see him anymore. We took him to the woods and said, run free. Makes sense. Yeah. So I do carry the ginger gene. And if she had carried the ginger gene, that would have been a deep concern. But she luckily doesn't. And so that was one of the key tests. You progressed to the second date. Yes. So we made it to the second date. What does no one know about nuclear that everyone should know about nuclear? That it is very safe. I think... And that it's not a science or engineering problem. That was... When we started looking at companies to invest in, that was, for me, the thing that I was disappointed by, is everybody was approaching it as if nuclear is this massive engineering challenge. And sure, the engineering is hard. It is complicated. But fundamentally, we have built safe nuclear reactors since the 60s. They work great. The technology has not really changed or progressed since then. We know how to build these. That's not the problem. The problem is that, due to a lot of the anti-nuclear push in the 80s, we have had a regulatory environment that has been incredibly restrictive and difficult to get new nuclear reactors built, particularly in the US, but also worldwide. There's been this push to say, how do you guarantee that under any possible circumstance, once-in-a-million-year events, that you will never have anything go wrong? And in traditional nuclear, that is very hard to guarantee. In traditional nuclear, one of the reasons it's difficult, you're basically balancing on this knife edge. So in a reactor, you have what's called criticality, right? Which is where you have to produce enough neutrons each generation that they go off and do exactly one more reaction, and it keeps itself going. If you get too much of that, too many neutrons, it's a bomb, right? It will be a runaway reaction and it will blow up. That's very bad. That's only ever happened once by accident, which is Chernobyl. All the others have not been criticality events. So you don't want that. If it happens not enough, then it just turns off. So if you go too far below this exact 1.0 threshold, you get no power out. And so you're trying to balance perfectly on that knife edge of exactly 1.0, where you can control it. And that is a hard problem to guarantee. And this is the fundamental issue with nuclear regulation. How do you guarantee that under no possible circumstances will you deviate from that perfect control? And so I was initially pretty disheartened. I was like, well, we're not going to get new nuclear power. This is not going to work. And then I stumbled on this idea of what's called the energy amplifier. And it's not a new technology. It's been around since the late 80s, early 90s. It was really pushed by a guy, Carlo Rubio, who used to be the CERN director. He was a Nobel laureate in physics. And the idea is you always operate below that 1.0 threshold. So we are designed to operate at 0.97. So that means you never have enough neutrons to keep the reaction going. The reaction will always fizzle out. So no matter what you do, it's going to fizzle out. But normally that would mean you get no power output. What you do in the energy amplifier is you point a really powerful particle accelerator at that fuel. And that puts in the extra neutrons to drive the reaction forward. But if you turn that accelerator off, all of your energy output just stops. And so you basically have this big on-off switch where you can control fission. And you can guarantee that no matter what you do to it, the fission will never run away. Even if you put in 10 times as much power from the accelerator, it will never run away. There's nothing you can do to it to cause it to go critical or to have a criticality accident. And so it's a fundamentally safer way of doing nuclear fission that is just approaching it from a different angle. How will the composition of our energy providing change in the next 5 to 10 years? Will nuclear be a demonstrably larger part of energy provision than it is today? Yes. I think what we're seeing all across the supply chain in nuclear is a push to get more nuclear online. And I think Subcritical is leading the way there, with a faster path to market than any of the other players. But there's a lot of people working on deploying a lot of new nuclear power. Which current provision will diminish significantly? I think any power from coal will mostly go away. I think you're still going to see a lot of gas just because, particularly in the US, it's cheap. It works. It's fast. But I think coal is going to go away. And then you're just going to see more of everything. What company will be larger? Curative or Subcritical? Subcritical, yeah. Or Subcritical? That's a great question. Curative has a larger market opportunity, but I think they're both... Has a larger market opportunity? Yeah. I think they're both... The power generation? Yeah. The US spends... Or US employers spend $1.5 trillion a year on healthcare, which is... That's our direct TAM every single year. How much does the US spend on energy? Through energy that can be addressed through nuclear. It's a similar order of magnitude. I mean, you chose good TAMs. They're both going to be... From milk yield optimization. I feel like you've really taken this... I figured out the TAM thing. No, they're both trillion-dollar opportunities if we execute right. Right. Fuck. Yeah. Wow. We're also seeing AI on the nuclear side and the design. Because design is traditionally a thing that is done by a whole bunch of people sitting, doing drawings and mechanical engineering. And the models have gotten really good at that. And so we're seeing that you can do the design with far fewer people, using AI to optimize a lot of the design parameters. Where historically you might have needed 100 mechanical engineers to design every single nut and bolt and part, you can do it with 20 really good mechanical engineers that are designing the critical pieces, the important pieces, and overseeing the AI on, oh, well, I need a little bracket that joins this piece to this piece. It doesn't need a human to design that. I was actually meeting a company the other day which basically said, the challenge with hardware engineers is they don't often know software engineering. And the beauty of today is we've turned hardware engineers into software engineers overnight. Yep. And that's amazing. But it's another place where we saw CodeGen as a solution. And I think this is one of the bets Anthropic made, and they're totally right on. You can generate really good CAD models by having it write Python to make the CAD model. It's not necessarily good at 3D space visualization or outputting a drawing right as vectors. But it's really, really good at generating plausible Python code that can draw that part. It is the most exciting time to be alive in many respects. Yeah. Yeah. Well, that's why we ended up starting Subcritical. I was very busy running Curative, but that was an idea that was just too important to pass up. And there was nobody else. So the only one that is under active construction of those systems is in China, based on a U.S. design from the 2010s that the U.S. stopped working on after Fukushima. How much money do you need to make Subcritical significant? Well, each one of our deployments would be about a billion dollars of construction cost for a 300 megawatt facility. So it's... But it's not... It wouldn't be the same, you wouldn't raise that as equity. It would be a mix into the plant of equity and debt. So it's a different kind of... It's more infrastructure-build financing. What do you know now about marriage that you wish you'd known at the beginning? Seriously, it's an amazing thing to build a company with your wife. Yes. It's a challenging thing as well. Yes. How do you make it work? So we're very well matched, I think, is one of the things. We basically never argue. And that's how I knew very early on that it was meant to be, is we're always on the same page about things. And so it's actually very easy to run a company together because we usually see eye to eye on how something should be done. Fatherhood? You said two kids. Two kids. Two-and-a-half-year-old and six months. Anything that you would advise a new father, knowing what you know now? You should definitely have kids. Don't wait. I think there's too much sentiment of people, oh, live your life and wait until you're in your late thirties and then have kids. I think not. Have kids early, when you have the energy and can run around and not sleep. And it's one of the best things you'll ever do. So we're very well matched. I think one of the things is we never argue. And that's how I knew very early on that it was meant to be. We're always on the same page about things. And so it's actually very easy to run a company together because we usually see eye to eye on how something should be done. Fatherhood? You said two kids. Two kids. Two and a half year old and six months. Anything that you would advise a new father, knowing what you know now? You should definitely have kids. Don't wait. I think there's too much sentiment from people. Oh, live your life and wait until you're in your late thirties and then have kids. I think, no, have kids early when you have the energy and can run around and not sleep. And it's one of the best things you'll ever do. You should just get on with it. Okay. We're going to do a quick follow. Sound good? Yep. Dude, that was the most twisting and turning conversation ever, from the proliferation of STDs to fatherhood and nuclear. I mean, really, we crushed it. What have you changed your mind on most in the last 12 months? I think probably a year ago, I would have said there are workflows that can't be done with today's models. I think today, the current gen models can do every back office task we have at Curative. It's just a matter of deploying them, getting them set up, getting them configured, having the right policies. And I think a year ago, I thought there was opportunity. I thought there were things we could do, but I don't think I would have said you could do every single one of our current back office flows. What one change would you make to Europe if I made you president of Europe, in this very strange title, to stay in the race for competitiveness? You have to have some kind of burden for passing regulation. There needs to be some penalty. Right now, you pass a regulation that's like, okay, you did a good job. The goal is to pass regulation. There has to be some penalty. If you pass regulation, your country must pay some additional tax for having passed that regulation. Just adding and adding and adding without refining what you've got today and really going and digging in how this regulation is affecting things on the ground, just more additive regulation is bad. You need to be looking at the effect of what you've done and refining it and iterating on it and not just trying to add some new landmark regulation. That's very anti-European, Fred. I don't know what I mean very well. I moved for a reason. I'm a Texan now. Mark Benioff said he spent $300 million on Anthropic, equated across the developers that they have. It works out to be about 3.8% of developer salary spent on Anthropic. What do you think total percent of developer salary spend will be on Anthropic in three years' time? Between maybe 2 and 5x would be the 2 and 5x salary. I think that's probably... 2 to 5x is the whole salary? Yeah. Whoa. So from 3.8% of salary... Yeah, because I think the way we're driving workflows is that you have one senior engineer managing a bunch of downstream agents that are actually doing the work. And then we're now getting to the point where you have mostly unsupervised agents taking feedback from the team on things, implementing features. And then the engineers are coming in and actually checking that what it built makes sense. So they're becoming more the reviewer and the architect. And then you have these downstream agents doing the work. 2 to 5x. I mean, that's not like 3.8% to 20%. 50%. If it's 50% Anthropic, it's like a $20 trillion company. Yeah. I think that what the workflows will be is people are going to be deploying more agents than engineers. And they're going to keep the same number of engineers. We're just going to build a lot more. Just a message, my friend, to let me into that new Anthropic round. Just a message, Larry. There we go. What's the kindest thing anyone's ever done for you? I think when I first was getting started, there were a lot of people that helped make it possible to move to the U.S. and made a bet on a kid coming from the north of England to come to Silicon Valley. Some of the earliest investors, the guy Josh Buckley, who was one of the first guys who invested in it during the YC batch. Josh, just because he liked what we were doing and he thought it was cool. But being willing to take a bet on a kid. Josh is my best friend. I didn't know that. I haven't seen him in a while. Yeah. I speak to Josh every single night. Okay. Barring, say, Christmas. All right. Well, he invested in cows. That is unbelievable. And then STDs. I invest in market fit. That's amazing. I didn't know that on Josh. Yeah. Yeah. A month into the YC batch, he came by the lab and was super supportive of what we were doing. And I think just coming from the British background, we couldn't even get meetings with investors. And he was young. I mean. He was, yes. But to get, I mean, he'd been through YC and had a successful company. And it was just awesome to have someone like that take a bet on what you're doing. Coming from the UK, where I was used to the cold shoulder and no one was interested in what I was building and no one wanted to take a meeting. That makes me so happy to hear. Okay. Final one. What was the best advice that you've been given? I think one thing that I have learned is to always try and get a lot of different perspectives on a problem. I think I would historically have approached things from one scientific viewpoint. And sometimes people would say, no, take a step back and think about that problem more broadly. And one of the things I learned during the curative COVID push is we had to bring together a bunch of people from very different backgrounds. We hired a bunch of former military people who were just incredible at deployment, but they speak a different language. And then we're trying to get them to talk to scientists. And then we hired a bunch of Silicon Valley developers. And they all think about the problem. They're all trying to solve the problem, but they all come at it from a completely different perspective. And a lot of times I wouldn't have considered that point of view on doing it. And I think what I found is that the more of those perspectives that you can get on a problem, the closer to ground truth you get. You're never going to, no, no one of those people is going to give you the ground truth. But if you hear a lot of perspectives, you can get to that ground truth faster. Fred, that was the most extraordinary show that I've ever done in breadth, depth, variance of conversation. Thank you so much for joining me. And it's so great to do it in person. Yeah. Thanks for having me. And it's one of the best things you'll ever do. You should just get on with it. Okay. We're going to do a quick follow. Sound good? Yep. Dude, that was the most twisting and turning conversation ever from like the proliferation of STDs to fatherhood and nuclear. I mean, really, we crushed it. What have you changed your mind on most in the last 12 months? I think probably a year ago, I have changed my mind that there are workflows that can't be done with the models, with today's models. I think today, the current gen models can do every back office task we have at Curative. It's just a matter of deploying them, like getting them set up, getting them configured, having the right policies. And I think a year ago, I thought there was opportunity. I thought there was things we could do, but I don't think I would have said you could do every single one of our current back office flows. What one change would you make to Europe if I made you president of Europe in this very strange title to stay in the race for competitiveness? You have to have some kind of like burden for passing regulation. There needs to be some penalty. Like right now, you pass a regulation that's like, okay, you did a good job. Like the goal is to pass regulation. There has to be some penalty. Like if you pass regulation, your country must pay some tax, additional tax for having passed that regulation. Just adding and adding and adding without like refining what you've got today and like really going and digging in how is this regulation affecting things on the ground? Like just more additive regulation is bad. You need to be looking at the effect of what you've done and refining it and iterating on it and not just trying to add some new landmark regulation. That's very anti-European, Fred. I don't know what I mean very well. I moved for a reason. I mean, I'm a Texan now. Mark Benioff said he spent $300 million on Anthropic, equated across the developers that they have. It works out to be about 3.8% of developer salary spent on Anthropic. What do you think total percent of developer salary spend will be on Anthropic in three years' time? Between maybe 2 and 5x would be the 2 and 5x salary. I think that's probably... 2 to 5x is the whole salary? Yeah. Whoa. So from 3.8% of salary... Yeah, because I think the way... I mean, the way we're driving workflows is that you have one senior engineer managing a bunch of downstream agents that are actually doing the work. And then we're now getting to the point where you have like mostly unsupervised agents taking feedback from the team on things, implementing features. And then the engineers are coming in and actually checking that what it built makes sense. So they're becoming more the reviewer and like the architect. And then you have these downstream agents doing the work. 2 to 5x. I mean, that's not like 3.8% to 20%. 50%. If it's 50% Anthropic, it's like a $20 trillion company. Yeah. I think that that's what the workflows will be is people are going to be deploying more agents than engineers. And they're going to keep the same number of engineers. We're just going to build a lot more. Just a message, my friend, to let me into that new Anthropic round. Just a message, Larry. There we go. What's the kindest thing anyone's ever done for you? I think when I first was getting started, there were a lot of people that helped make it be possible to move to the U.S. and kind of like made a bet on a kid coming from the north of England to come to Silicon Valley. Like some of the earliest investors, the guy, Josh Buckley, who was one of the first guys who invested in it during the YC batch. Josh just because he liked what we were doing and he thought it was cool. But, you know, being willing to kind of take a bet on a kid. You know, Josh is like my best friend. I didn't know that. I haven't seen him in a while. Yeah. I speak to Josh every single night. Okay. Barring, say, Christmas. All right. Well, he invested in cows. That is unbelievable. And then STDs. I, you know, invest a market fit. That's amazing. I didn't know that on Josh. Yeah. Yeah. He like a month into the YC batch, like came by the lab and was like super supportive of what we're doing. And I think just coming from like the British background, we couldn't even get meetings with investors. And he was young. I mean. He was, yes. But to get, I mean, he'd been through YC and had a successful company. And it was just awesome to like have someone like that take a bet on what you're doing. Coming from the UK where I was used to like the cold shoulder and no one was interested in what I was building. And, you know, no one wanted to take a meeting. That makes me so happy to hear. Okay. Final one. What was the best advice that you've been given? I think one thing that I have learned is to always try and get a lot of different perspectives on a problem. I think I would historically have sort of approached things from like one scientific viewpoint. And sometimes people would say, no, like take a step back and think about that problem more broadly. And one of the things I learned during the curative COVID push is we had to bring together a bunch of people from very different backgrounds. We hired a bunch of former military people who were just like incredible at deployment, but they speak a different language. And then we're trying to get them to talk to scientists. And then we hired a bunch of Silicon Valley developers. And they all like think about the problem. They're all trying to solve the problem. But they all come at it from like a completely different perspective. And a lot of times I wouldn't have considered, you know, that point of view on doing it. And I think what I found is that the more of those perspectives that you can kind of get on a problem, the closer to ground truth you get. Like you're never going to, no, no one of those people is going to give you the ground truth. But if you hear a lot of perspectives, you can kind of get to that ground truth faster. Fred, that was the most extraordinary show that I've ever done in breadth, depth, variance of conversation. Thank you so much for joining me. And it's so great to do it in person. Yeah. Thanks for having me.